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In both in vitro and in vivo studies, Epitalon treatment is associated with increased TERT expression, elevated telomerase enzymatic activity (TRAP assay), and measurable preservation of telomere length as assessed by quantitative-FISH (Q-FISH) and Southern blotting of terminal restriction fragments (TRF)

Sweeteners such as sorbitol or sucralose might have a similar effect

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They were individuals with obesity or overweight, many with type 2 diabetes

SPE can be applied directly in gas-solid phase and liquid-solid phase, or indirectly to solid samples